50-year-old Asian women who was a non-smoker was diagnosed with lung adenocarcinoma. Histology assessment demonstrated an acinar pattern.

SEM2-CELLPATH

Instructions:

Portfolio- poster and case study report. L6 SCENTIFIC LANGUAGE AND APPROACH

Learning outcomes

  • Discuss the underlying pathological processes of selected disease.
  • Relate the molecular and cellular aetiology and pathological process to the detection, diagnosis, treatment and monitoring of selected disease.
  • Relate A research evidence-based knowledge of pathological mechanisms to histology- based diagnosis, /clinical diagnostic methods and disease monitoring.

Case study 3:

50-year-old Asian women who was a non-smoker was diagnosed with lung adenocarcinoma. Histology assessment demonstrated an acinar pattern. Additional tests were performed to determine the molecular basis of disease and the most appropriate course of treatment. The patient was identified as harbouring an EML4-ALK translocation.

This assignment is split into 2: All

  • CASE STUDY REPORT – 750 words + 10%
  • POSTER – 750 words +10%                              Total is 1500 words + 20%

Section 1- CASE STUDY REPORT

Prepare a report of the case study above to meet the first learning outcome listed above.

Analyse the case study, making references to it, link pathology to the patient’s symptoms.

Background of the disease and how it occurs.

  • What is the pathological basis of disease given in the above case study?
  • Is it linked to environmental and/or genetic alterations?
  • Describe these processes.
  • Link the pathology to the symptoms/findings of the case study listed above.

This needs to be a detailed account of how disease occurred in the case study.

Relate your findings to research-based knowledge using primary research papers.

Ensure the use of headings/subheadings, good organisation, use figures, illustrations, tables where appropriate.

Please evidence your research with the use on in-text citations and a full Harvard reference list

Section 2- POSTER

This section is carrying on from section 1 and its case study. This section 2 needs to be presented as a poster with all of the information below,

Once you have established and researched the aetiology and pathological process of your named disease, from completing the case report in SECTION 1….

  • You must discuss laboratory methods used for diagnosis.
  • Evaluate the current methods in use in a cellular pathology laboratory, clearly describing the methods.
  • Identify strengths and weaknesses and highlight recent advances that have been implemented or likely to be used in the future.

THIS INCLUDES:

  • How would this disease be detected/diagnosed? Think of relevant cellular pathology techniques (H&E staining)
  • What additional tests are involved? IHC, special stains, Molecular tests (include all if relevant)
  • Summarise these techniques – tissue requirement, processing, dissection etc.
  • Explain the results (the use of figures, tables, images may be useful here) ensure you annotate images of staining to demonstrate your understanding of relevant cellular, architectural changes, where relevant.
  • How would this patient be treated and monitored?
  • What are the treatment pathways and how do they link to the pathology?
  • What is the patient prognosis?
  • Include limitations of techniques and treatments.

Please evidence your research with the use on in-text citations and a full Harvard reference list