Review article originally rejected but strongly encouraged by editor to resubmit after correcting significant errors. Please enhance original manuscript&cover letter, to include qualitative changes (ie critical analysis) as well as correct for semantic errors; and double check the recommended changes (both listed and presented in comment form from the reviewers comments–uploaded ). Lastly, increase word count by 500-600+ words. Please refer to the attached original manuscript, and the edited one “MicrorubMM2”, cover letter, and the reviewer comments with my suggestions.Review article originally rejected but strongly encouraged by editor to resubmit after correcting significant errors. Please enhance original manuscript&cover letter, to include qualitative changes (ie critical analysis) as well as correct for semantic errors; and double check the recommended changes (both listed and presented in comment form from the reviewers comments–uploaded ). Lastly, increase word count by 500-600+ words. Please refer to the attached original manuscript, and the edited one “MicrorubMM2”, cover letter, and the reviewer comments with my suggestions.