1. Compare and contrast the evolution of Plasmodium falciparum with that of Trypanosoma brucei gambiense (group 1). That is, identify major similarities or differences and their predicted impact on the long-term fitness of each parasite.

2. Positive (or diversifying) selection is a predicted outcome of successful adaptation to a new host and should be detectable in a dataset like the one presented here. Did the authors look for and identify genes that were positively selected after the transfer to humans? If so, how many and what kinds of biological roles do they have?2. Positive (or diversifying) selection is a predicted outcome of successful adaptation to a new host and should be detectable in a dataset like the one presented here. Did the authors look for and identify genes that were positively selected after the transfer to humans? If so, how many and what kinds of biological roles do they have?