Based on my specific Cell signaling area which is the TGF beta pathway, you will have to select a specific topic of recent research (2016-2018) (Published journal), within that area to propose design a short proposal (3 month study) of further experimental research based on the topic. Proposal Layout will be according to NIH Proposal Outline which will be attached below.
So basically you have to review recent scientific literature (2016-2018) on the TGF beta pathway, identify a gap in knowledge on the subject. Having identified the question that needs answering, we have to develop a hypothesis and design an experiment to test the hypothesis. This will be in the form of a grant proposal. Which has to follow the NIH guidelines for grant proposals. Which I will attach as a file. Please include all sources on the last page as a reference page!