Ayres, J. S., & Schneider, D. S. (2012). Tolerance of infections. Annual review of immunology, 30, 271-294.
The hypothesis of the paper was pathogen tolerance play an important part in understanding of disease and infections treatment and vaccinations.- 2. Figure 1: Resistance and Tolerance graphical definition
- The purpose of the experiment was to determine the relationship between microbe load, resistance and tolerance.
- Data was collected for patients who had microbe infections after getting sick and recovering. The microbe load and health of the individual were determined and then plotted on a two-dimension graph. The study was measuring tolerance.
- The control of the experiment was healthy status at zero parasite loads, Vogor.
- There is a relationship between microbe load, resistance and tolerance.
- Tolerance can be measured through use of adequate data
Figure 2: Immunological mechanism
- Measuring tolerance based on different elicitors.
- It was done through activation of TLR4 using different microbes. Deferent tolerance and resistance of immune response
- Alkaline phosphatase was useful in determining the effect of LPS in immune response
- TLR4 leads to activation of pathology and prevention of bacteria from infection, tolerance and loss result in defects in resistance
- TRL4 play major role in tolerance and resistance
Figure 3: microbe space and health
- Measuring individual resistance and tolerance based on health properties.
- The study started with a healthy sample and changes in properties monitored with respect to resistance and tolerance.
- The control of the healthy sample at the initial position before experiencing resistance or tolerance
- Changes in host environment results to changes in health thus is reflected by increase or decrease in either resistance or tolerance
- Changes in health has effect on resistance and tolerance of the host
Figure 4: Tolerance classes
- Explain various tolerance classes
- Through analogous explanations
- Different types of tolerance
- There are different types of tolerance depending the immune response of the host
- Immune response is important in development of resistance and tolerance
- Conclusion
Tolerance and resistance play important role in understanding treatment of various microbes. Tolerance and resistance depends on elicitor, health status, microbe space, and immune response.