The role of DNA repair in resistance to topoisomerase inhibitors and nucleoside analogues
The literature view should review background published research literature relating to the specific research topic chosen.
The format of the review must follow that of a full review published in the Journal Cell.
- Word count, excluding bibliography, must be included on the first page of the document
- A list of 4 Key words (for database searching)
- 5 figures.
- A maximum of 100 references are allowed and not less than 30 references
Guidance for Formatting:
- Double sided, A4 paper size, 2.54cm, top, bottom, left and right margins
- Main text, and figure legends Arial 10-point font, single-spaced text
- All pages numbered
- Single-column format for cover page, title, references, footnotes, figures and tables.
- Two-column format for summary, introduction, results and discussion sections. See below for help converting text into columns with Microsoft Word.
- Once you have completed your report, select text to be converted to columns
- Click on “Format,” and then choose “Columns” from the drop-down menu.
- Select two columns and equal column width with spacing of 0.5 cm
The structure of the research paper
- Introduction (here you should introduce the main headings listed bellow linking them together to give the reader a hint of what will be discussed in details after. So use 300 words only in here.
- DNA damage, repair and cancer (you should use subheadings and you should introduce the role of MRN (Mre11-Rad50-Nbs1) complex while you are explaining within DNA damage, repair and cancer. (read the articles uploaded to discuss this in full scientific details, you have to reference everything, do not use short sentences, do not use no-sense sentences. see the following graph to explain it in full details and you can see the reference of this figure uploaded .
- Role of DNA repair in resistance to topoisomerase inhibitors (very brief summary)
- Role of DNA repair in resistance to nucleoside analogues (you have to be very scientific in details here as this is the core of the project)
- Developing novel Mre11 exo- and endo-nuclease inhibitors (this is the core as well so be scientific )
- Conclusion (Just a brief conclusion of the overall and the importance to study the title of this project).
Please read the slides uploaded with this to have clue what the research paper is about and you have to include all the above heading and explain them in scientific details.
