Using the questions to address when prescribing a medication, determine the best medication to prescribe to the patient. What are the first line, second line, and third line therapies when prescribing a medication?

A 32-year-old woman comes to the acute care clinic. She states, “I have pain in my knees. I can barely walk up and down stairs.” She weighs 145 pounds and is 5′ 2″. During your assessment, you note her knees have a very small amount of swelling with warmth or redness. You diagnose her with the initial stages of osteoarthritis. She has no allergies and takes trazodone hydrochloride 50 mg PO at night to assist with sleeping and to prevent TMJ symptoms. You determine she needs an anti-inflammatory agent. Using the questions to address when prescribing a medication, determine the best medication to prescribe to the patient.
What are the first line, second line, and third line therapies when prescribing a medication?